Abstract: Objective To compare and analyze the biological characteristics of BALB / cSpf mice and wild-type BALB / c ( N-BALB / c, N: normal ) mice, and to provide basic data for its experimental application. Method From 3 to 12 weeks, the growth curves, feed intake and water intake of male and female BALB / cSpf mice and N-BALB / c mice were statistically analyzed weekly. Thirty female BALB / cSpf mice and thirty female N-BALB / c mice were collected, two females and one male cohabitated and bred for a long time. The litter size and litter sex were recorded. Blood was collected and 17 blood biochemical indexes and 22 blood physiological indexes were measured. Result there was no significant difference in feed intake and drinking water between BALB / cSpf mice and N-BALB / c mice. The body weight of BALB / cSpf mice was significantly higher than that of N-BALB / c mice ( from the 5th week in females and from the 3rd week in males) . There was no significant difference in litter size and sex in the first three births. The physiological indexes of WBC, Neu, Lym, RBC, HGB, HCT, MPV and PDW in female BALB / cSpf mice were significantly higher than those in N-BALB / c mice. The WBC of male BALB / cSpf mice was significantly higher than that of N-BALB / c mice, while the levels of Neu, Lym, Mon, HCT and MCHC were significantly lower than those of N-BALB / c mice. The UREA of female BALB / cSpf mice was significantly higher than that of N-BALB / c mice, while the levels of AST, CK and LDH were significantly lower than those of N-BALB / c mice. The biochemical indexes TG, TC, LIP, UREA and Mg Ⅱ of BALB / cSpf mice were significantly higher than those of N-BALB / c mice, while ALT, AST, Glu-G and Ca were significantly lower than those of N-BALB / c mice. Conclusion there are some differences in biological characteristics between BALB / cSpf mice and N-BALB / c mice.

Key words: BALB / cSpf mice, BALB / c mice, biological characteristics

摘要： 目的 比较分析 BALB / cSpf 小鼠与野生型 BALB / c(N-BALB / c,N:normal) 小鼠生物学特性指标差异,为其实验应用提供基础数据。 方法 3 ~ 12 周,每周对雌雄 BALB / cSpf 小鼠和 N-BALB / c 小鼠生长曲线、采食量、饮水量进行统计分析;取 BALB / cSpf 小鼠雌性和 N-BALB / c 小鼠雌性各 30 只,二雌一雄长期同居交配方式繁殖饲养,记录产仔数,产仔性别;采集血液进行 17 项血液生化指标和 22 项血液生理指标测定。 结果 BALB / cSpf 小鼠和 N-BALB /c 小鼠采食量和饮水量差异不显著( P> 0. 05) ,BALB / cSpf 小鼠体质量显著高于 N-BALB / c 小鼠( 雌性从第 5 周开始,雄性从第 3 周开始) 。 1 ~ 3 胎产仔数及产仔性别差异不显著。 雌性 BALB / cSpf 小鼠生理指标 WBC、Neu、Lym、RBC、HGB、HCT、MPV、PDW 显著高于 N-BALB / c 小鼠(P< 0. 01) 。 雄性 BALB / cSpf 小鼠生理指标 WBC、Neu、Lym、Mon、HCT、MCHC 显著低于 N-BALB / c 小鼠(P<0. 01) 。 雌性 BALB / cSpf 小鼠生化指标 UREA 显著高于 N-BALB / c小鼠(P<0. 05) ;AST、CK、LDH 显著低于 N-BALB / c 小鼠(P<0. 01) 。 BALB / cSpf 小鼠生化指标 TG、TC、LIP、UREA、MgⅡ显著高于 N-BALB / c 小鼠(P<0. 01) ;ALT、AST、Glu-G、Ca 显著低于 N-BALB / c 小鼠( P<0. 01) 。 结论 BALB /cSpf 小鼠和 N-BALB / c 小鼠生物学特性有一定差异。

关键词: BALB / cSpf 小鼠, BALB / c 小鼠, 生物学特性